Malonic acid is an alpha,omega-dicarboxylic acid in which the two carboxy groups are separated by a single methylene group. It has a role as a human metabolite. It is a conjugate acid of a malonate(1-).
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Addition of malonates 4 to glycals 6. Method A: 4 equiv CAN; method B: 4 equivCAN, 0.5 equivwater; method C: 4 equivanhy-drous CAN. Yields of isolated products after column chromatography are indicated in parentheses.