(+)-Duocarmycin SA
CAS number: 130288-24-3
(+)Duocarmycin SA (DSA) is a highly potent antitumor antibiotic and cytotoxic agent belonging to the duocarmycin family of natural products derived from the bacterium Streptomyces. It was first isolated in 1990 from a Streptomyces strain found in Kyoto, Japan.
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Duocarmycin SA (1a), pseudo-dimeric prodrug 1b, and prodrugs (-)-(S)-2a and (+)-(1S,10R)-2b to give the cytotoxic drugs 4a and 4b via the seco-drugs (+)-(S)-3a and (+)-(1S,10R)-3b. Cytotoxic drugs 4a and 4b share the spirocyclopropylcyclohexadienone moiety with 1a.
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