N-Bromosuccinimide
CAS number: 128-08-5
N-bromosuccinimide is a five-membered cyclic dicarboximide compound having a bromo substituent on the nitrogen atom. It has a role as a reagent.
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Formation and reaction of PdII complex 2. NBS = N-bromosuccinimide, NCS = N-chlorosuccinimide.
![Synthesis of aminyl diradicals 1 and 2. a) NBS in chloroform, NaHCO3, Na2SO4, -40℃ for 1 h, then 08C for 2 h, 35%. b) 4-tert-butylphenylboronic acid or 4-tert-undecylphenylboronate, [Pd(PPh3)4], Na2CO3, benzene/EtOH/water, 908C (5: 62% yield, 6: 43% yield). c) nBuLi (2.4 equiv), THF/hexane, ca. -30℃ for 1 h, then solvent change to THF or 2-MeTHF, and I2 (1.06 equiv) at -90℃ or titration with I2 at -90 to -115℃ monitored by EPR spectroscopy. NBS=N-bromosuccinimide.](http://www.wlxkc.cn/picture/3912354_05.png)
Synthesis of aminyl diradicals 1 and 2. a) NBS in chloroform, NaHCO3, Na2SO4, -40℃ for 1 h, then 08C for 2 h, 35%. b) 4-tert-butylphenylboronic acid or 4-tert-undecylphenylboronate, [Pd(PPh3)4], Na2CO3, benzene/EtOH/water, 908C (5: 62% yield, 6: 43% yield). c) nBuLi (2.4 equiv), THF/hexane, ca. -30℃ for 1 h, then solvent change to THF or 2-MeTHF, and I2 (1.06 equiv) at -90℃ or titration with I2 at -90 to -115℃ monitored by EPR spectroscopy. NBS=N-bromosuccinimide.
Bromolactonization of compound 6h. NBS=N-bromosuccinimide.
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