Diethylene Glycol
CAS number: 111-46-6
Diethylene glycol appears as a colorless liquid. Denser than water. Contact may slightly irritate skin, eyes and mucous membranes. May be slightly toxic by ingestion. Used to make other chemicals.
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![Scheme 5 outlines the synthesis of 1a analogue 6. Treatment of 20 with hydrazine and potassium hydroxide in refluxing diethylene glycol (DEG) afforded 21. Compound 21 was cyclized to 22 using polyphosphoric acid (PPA). Subjection of 22 to acetamidobenzenesulfonyl azide (ABSA) in acetonitrile containing 1,4-diazabicyclo[5.4.0]undec-7-ene (DBU) yielded the diazo compound 23. Treatment of 23 with tert-butylamine in dry toluene in the presence of ruthenium acetate provided 6.](http://www.wlxkc.cn/picture/5213099_08.png)
Scheme 5 outlines the synthesis of 1a analogue 6. Treatment of 20 with hydrazine and potassium hydroxide in refluxing diethylene glycol (DEG) afforded 21. Compound 21 was cyclized to 22 using polyphosphoric acid (PPA). Subjection of 22 to acetamidobenzenesulfonyl azide (ABSA) in acetonitrile containing 1,4-diazabicyclo[5.4.0]undec-7-ene (DBU) yielded the diazo compound 23. Treatment of 23 with tert-butylamine in dry toluene in the presence of ruthenium acetate provided 6.
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