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Potassium phthalimide
CAS number: 1074-82-4
Potassium phthalimide is the potassium salt of phthalimide, used as an intermediate in the synthesis of primary amines (via the Gabriel synthesis) and also in the production of pharmaceuticals, pigments, and dyes.

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Synthesis of alkyne terminated heterobifunctionalized OEG linkers. Reagents and conditions: (a) Propargyl bromide, NaH, THF, 0 °C–RT–60 °C, 15 h; (b) 4-nitrophenyl chloroformate, pyridine, MeCN, RT, 15 h; (c) MsCl, Et3N, DCM, 0 °C–RT, 3.5 h; (d) NaI, acetone, 65 °C, 15 h; (e) KSAc, DMF, RT, 15 h; (f) LAH, THF, −10 °C–RT, 3 h; (g) Potassium phthalimide, DMF, 110 °C, 15 h; (h) Hydrazine, EtOH, 60 °C, 3 h; (i) N-methoxycarbonyl maleimide, Sat. aq NaHCO3, 0 °C–RT, 2 h.
Synthesis of alkyne terminated heterobifunctionalized OEG linkers. Reagents and conditions: (a) Propargyl bromide, NaH, THF, 0 °C–RT–60 °C, 15 h; (b) 4-nitrophenyl chloroformate, pyridine, MeCN, RT, 15 h; (c) MsCl, Et3N, DCM, 0 °C–RT, 3.5 h; (d) NaI, acetone, 65 °C, 15 h; (e) KSAc, DMF, RT, 15 h; (f) LAH, THF, −10 °C–RT, 3 h; (g) Potassium phthalimide, DMF, 110 °C, 15 h; (h) Hydrazine, EtOH, 60 °C, 3 h; (i) N-methoxycarbonyl maleimide, Sat. aq NaHCO3, 0 °C–RT, 2 h.
DOI: /10.1039/c2ob26968f

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